By Werner E. G. Müller, Heinz C. Schröder, Xiaohong Wang
This publication describes the invention of molecules from unexploited severe marine environments, and provides new techniques in marine genomics. It combines the present country of information in marine genomics and complicated average items’ chemistry to pursue the sustainable creation of novel secondary metabolites (lead compounds), in addition to pharmacologically lively peptides/proteins, with antimicrobial, neuroprotective, anti-osteoporotic, anti-protozoan/anti-plasmodial, anti-ageing and immune-modulating results. extra, it employs molecular-biology-based methods and complex chemical thoughts to procure and to pick candidate compounds for pre-clinical and medical studies.
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Aureus (MIC = 16 µg mL−1) and against the yeasts Candida albicans (IC50 = 32 µg mL−1) and Cryptococcus neoformans (IC50 = 8 µg mL−1). Manzamenone N also exhibited moderate antimicrobial activities against E. coli (MIC = 32 µg mL−1), C. albicans (IC50 = 32 µg mL−1), and C. neoformans (IC50 = 4 µg mL−1). According to the structure of the compounds, since Manzamenone L did not show any antimicrobial activity, the presence of a free carboxylic acid at C-5 position was reported as being important for the antimicrobial activities (Kubota et al.
Tetrahedron Lett 27 (28):3283–3284 Lidgren G, Bohlin L, Christophersen C (1988) Studies of Swedish marine organisms, part X. biologically active compounds from the marine sponge Geodia baretti. J Nat Prod 51(6):1277– 1280 Lind K, Hansen E, Østerud B, Eilertsen K-E, Bayer A, Engqvist M, Leszczak K, Jørgensen T, Andersen J (2013) Antioxidant and anti-inflammatory activities of barettin. Mar Drugs 11 (7):2655–2666 Lind KF, Østerud B, Hansen E, Jørgensen TØ, Andersen JH (2015) The immunomodulatory effects of barettin and involvement of the kinases CAMK1α and RIPK2.
2013) the ﬁrst chemical property space map of marine natural products was presented. From these preliminary analyses, complemented and reﬁned in the present study (Fig. 5), it was clearly demonstrated that there are fundamental differences between natural products found in marine and terrestrial organisms. These differences became more pronounced when the molecules grew larger, providing access to a wide variety of chemical properties. Methods for interpretation. There are several ways to interpret the map of chemical property space.
Blue Biotechnology: From Gene to Bioactive Product by Werner E. G. Müller, Heinz C. Schröder, Xiaohong Wang