Read e-book online Blood-Spinal Cord and Brain Barriers in Health and Disease PDF

By Hari Shanker Sharma

ISBN-10: 0126390118

ISBN-13: 9780126390117

  • '''Blood-Spinal twine and mind limitations in overall healthiness and illness' is a latest and extremely informative quantity that are supposed to be a prepared resource of reference for all researchers and clinicians excited by the CNS in well-being and disease.'' --Cerebrospinal Fluid examine (June 2005)

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Additional info for Blood-Spinal Cord and Brain Barriers in Health and Disease

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6 present immunocytochemical stainings for both proteins (ZO-1, A and B; occludin, C and D) when CP epithelial cells had been incubated in either medium supplemented with 10% FCS (A and C) or serum-free medium (B and D). Although the proteins are located exclusively at the cell borders between adjacent cells under both conditions, there are subtle differences. For cells that had been kept in serum-free medium (B and D), the immunofluorescence signal for both proteins is a sharp line without any protrusions or invaginations along the cell perimeter.

1994). In contrast, constitutive expression of VCAM-1 can be observed readily in comparable amounts on a small number of postcapillary venules and capillaries in the brain and spinal cord of healthy SJL/N mice with massive upregulation during EAE (Fig. 3) (Laschinger and Engelhardt, 2000). This suggests that VCAM-1 and ICAM-1 could already serve as ligands for encephalitogenic T-cell blasts during their initial recruitment across the healthy BBB into the CNS parenchyme. Nevertheless, as pointed out earlier, blocking the α4-integrin/ VCAM-1 but not the LFA-1/ICAM-1 pathway seems only to interfere with lymphocyte recruitment across the BBB in vivo.

For cells that had been kept in serum-free medium (B and D), the immunofluorescence signal for both proteins is a sharp line without any protrusions or invaginations along the cell perimeter. Those cells that were incubated in serumcontaining medium prior to immunocytochemical staining do not show such a sharp and focused localization of the corresponding proteins (A and C). Although these structural observations are not yet sufficient to explain the impairment of epithelial barrier function in the presence of serum, they demonstrate clearly that serum induces significant morphological alterations that are associated with barrier disintegration.

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Blood-Spinal Cord and Brain Barriers in Health and Disease by Hari Shanker Sharma


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