By Robert Lev
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the significant physique of simple technological know-how and scientific info linked to adenomatous polyps of the colon, a lot of it encouraged through the belief that the majority colorectal carcinomas appear to come up in such polyps. This ebook strives to judge those info, with specific emphasis on their implications for administration of polyp-bearing matters. themes comprehensively explored comprise anatomy and histology of the conventional colon; pathologic features of adenomatous polyps, differential analysis, and grading schemes for measure of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic facts for the malignant capability of adenomatous polyps; and detection and administration, with distinctive consciousness to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.
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Additional resources for Adenomatous Polyps of the Colon: Pathobiological and Clinical Features
1986). 32 2. Pathology APs have a lower percentage of aneuploidy than carcinomas; in one study (Goh & Jass, 1986), aneuploidy was found in 13 percent of 269 APs and in 64 percent of 203 carcinomas. , 1987). , 1987). , 1985), but these are exceptions to the generally good correlation between degree of aneuploidy (and other chromosomal and cell cycle abnormalities) and risk factors for carcinoma in APs. , 1988). That group concluded that 60 percent of the crater-shaped carcinomas develop from nonpolypoid (?
Kanemitsu T, Koike A, Yamamoto S (1985) Study of the cell proliferation kinetics in ulcerative colitis, adenomatous polyps and cancer. Cancer 56: 1094-1098. Kaye GI, Pascal RR, Lane N (1971) The colonic pericryptal fibroblast sheath: Replication, migration, and cytodifferentiation of a mesenchymal cell system in adult tissue. III. Replication and differentiation in human hyperplastic and adenomatous polyps. Gastroenterology 60:515-536. Kaye G, Fenoglio C, Pascal R, Lane N (1973) Comparative electron microscopic features of normal, hyperplastic and adenomatous human colonic epithelium.
There are very few data on the exact doubling times of polyps that are subsequently determined histologically to be benign, however. , 1984). 3 summarizes a recent review by Spratt and Spratt (1985) that shows doubling times from four earlier studies, including the Welin work cited above. 3. Mean doubling times for adenomatous polyps, carcinomas, and metastases. Polyps Carcinomas Metastases n Arithmetic mean (days) Range (days) 77 1,600 668 221 13-8,664 52-10,000 98 23 32-3,300 SOURCE: Modified from Spratt and Spratt, 1985.
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features by Robert Lev